Saving Lives, Protecting People, Shingles vaccination is the only way to protect against, National Center for Immunization and Respiratory Diseases, U.S. Department of Health & Human Services. In addition to the rash, shingles can cause fever, headache, chills, or upset stomach. You may have heard you can pass the virus to others if you get the Zostavax shingles vaccine. Bovine serum comes from blood taken from domestic cattle. The most common complication of shingles is long-term nerve pain called postherpetic neuralgia (PHN). Recombinant zoster (shingles) vaccine can prevent shingles. She . 80% of the proteins in cow's milk are casein. Proper citation depends on your preferred or required style manual. 2021), ProQuad Refrigerated Package Insert (Oct. 2018), Refrigerator-Stable Formulation: chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells, Frozen Formulation Recombinant Human Albumin (RHA): embryo cell culture; WI-38 human diploid lung fibroblasts, MRC-5 cells, Frozen Formulation Human SerumAlbumin (HSA): chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells, Frozen: chick embryo cell culture, WI-38 human diploid lung, MRC-5 cells, Refrigerated: chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells, Refrigerator-Stable Formulation: sucrose, hydrolyzed gelatin, urea, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate, recombinant human albumin, sodium bicarbonate, potassium phosphate, potassium chloride, residual components of MRC-5 cells including DNA and protein, neomycin, bovine serum albumin, other buffer and media ingredients, Frozen Formulation Recombinant Human Albumin (RHA): sucrose, hydrolyzed gelatin, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate dibasic, recombinant human albumin, sodium bicarbonate, potassium phosphate monobasic, potassium chloride; potassium phosphate dibasic, residual components of MRC-5 cells including DNA and protein, neomycin, bovine calf serum, other buffer and media ingredients, Frozen Formulation Human SerumAlbumin (HSA): sucrose, hydrolyzed gelatin, urea, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate, recombinant human albumin, sodium bicarbonate, potassium phosphate, potassium chloride, residual components of MRC-5 cells including DNA and protein, neomycin, bovine serum albumin, other buffer and media ingredients, Frozen: sucrose, hydrolyzed gelatin, sodium chloride, sorbitol, monosodium L-glutamate, sodium phosphate dibasic, recombinant human albumin, sodium bicarbonate, potassium phosphate monobasic, potassium chloride, potassium phosphate dibasic, residual components from the manufacturing process [MRC-5 cells including DNA and protein, neomycin, bovine calf serum, other buffer and media ingredients], Refrigerated: sucrose, sorbitol, hydrolyzed gelatin, urea, sodium chloride, sodium phosphate, monosodium L-glutamate, recombinant human albumin, sodium bicarbonate, potassium phosphate, potassium chloride, residual components from the manufacturing process [MRC-5 cells including DNA and protein, neomycin, bovine calf serum, other buffer and media ingredients], Meningococcal (Groups A, C, Y, and W-135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine, Manufacturer: GlaxoSmithKline Biologicals SA, Franz Complete medium, formaldehyde, CY medium [yeast extracts, amino acids], Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine, Mueller Hinton agar, Watson Scherp media [casamino acid], modified culture medium [hydrolyzed casein], formaldehyde, ammonium sulfate, sodium phosphate buffered isotonic sodium chloride solution, formaldehyde, Manufacturer: Novartis Vaccines and Diagnostics, Inc, Escherichia coli, deoxycholate, aluminum hydroxide, Neisserial adhesin A (NadA), Neisserial Heparin Binding Antigen (NHBA), factor H binding protein (fHbp), outer membrane vesicles (OMV), aluminum hydroxide, sodium chloride, histidine, sucrose, kanamycin. Centers for Disease Control and Prevention. Adverse reactions should be reported to the Vaccine Adverse Event Reporting System (VAERS). The two-dose vaccine is more than 90% effective at preventing shingles, the CDC reports. For some people, the pain can last for months or even years after the rash goes away. 2014 Aug 22; 63(33):729-731. 2011 Nov;7(11):1130-6. Healthcare providers should counsel patients about expected reactogenicity before administering Shingrix. You should plan to avoid strenuous activities, such as yardwork or swimming, for a few days after vaccination. Safety of zoster vaccine in adults from a large managed-care cohort: A Vaccine Safety Datalink study. It is not recommended to take these medications before vaccination. Most people have a sore arm after they get Shingrix. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. 14, 2016), Mueller Hinton casein agar, Watson Scherp casamino acid media, water, thimerosal, polysaccharide from each of serogroups A, C, Y, and W-135, lactose, Meningococcal (Groups A, C, Y, W) Conjugate Vaccine, Mueller Hinton agar medium, Watson Scherp medium, carbonyldiimidazole (CDI), adipic acid dihydrazide (ADH), periodate, ammonium sulfate, formaldehyde, sodium chloride, sodium acetate, formaldehyde, Pneumococcal 13-valent Conjugate Vaccine (Diphtheria CRM197 Protein), soy peptone broth, casamino acids and yeast extract-based medium, chemically-defined medium, ammonium sulfate, polysorbate 80, succinate buffer, aluminum phosphate. Zostavax is made from the whole but . The two doses should be separated by two to six months. Saving Lives, Protecting People, National Center for Immunization and Respiratory Diseases, U.S. Department of Health & Human Services. 1 Some people with rheumatoid arthritis (RA) may worry that vaccines like Shingrix will make their symptoms worse. J Intern Med. Package insert for Shingrix, U.S. Food and Drug Administrationpdf iconexternal icon, Shingles Vaccine Information Statement (Shingrix), National Center for Immunization and Respiratory Diseases, U.S. Department of Health & Human Services. Either administer it immediately, or store it in the refrigerator and use it within 6 hours of reconstitution. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. Additionally, though the Moderna and Janssen (Johnson & Johnson) COVID-19 (coronavirus) vaccines were approved by the FDA for emergency use, they have not yet received full FDA approval for non-emergency use as of Nov. 17, 2021, and thus are not included below. For most people, the second dose should be given 2 to 6 months after the first dose. Tdap Vaccine(tetanus, diphtheria, & pertussis), Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed, Stainer-Scholte medium, casamino acids, dimethylbeta-cyclodextrin, glutaraldehyde, formaldehyde, aluminum phosphate, Mueller-Miller casamino acid medium without beef heart infusion, ammonium sulfate, modified Muellers growth medium, aluminum phosphate, formaldehyde, glutaraldehyde, 2-phenoxyethanol, water, modified Latham medium derived from bovine casein, Fenton medium containing a bovine extract, formaldehyde, modified Stainer-Scholte liquid medium, glutaraldehyde, aluminum hydroxide, aluminum hydroxide, sodium chloride, formaldehyde, polysorbate 80 (Tween 80), Manufacturer: Pfizer Ireland Pharmaceuticals, chick embryo fibroblast (CEF) cells, formaldehyde, sucrose gradient, aluminum hydroxide, human serum albumin, aluminum hydroxide, sodium chloride, dibasic sodium phosphate, monobasic potassium phosphate, formaldehyde, sucrose, protamine sulfate, chick protein, DNA from CEF cells, neomycin, gentamicin, gelatin capsules, sucrose, ascorbic acid, amino acid mixture, lactose, magnesium stearate, Typhoid Vaccine Live Oral TTyphoid Vi Polysaccharide Vacciney21a, semisynthetic medium, casein derived raw materials, hexadecyltrimethylammonium bromide, formaldehyde, formaldehyde, phenol, polydimethylsiloxane, fatty-acid ester-based antifoam, isotonic phosphate buffered saline, sodium chloride, disodium phosphate, monosodium phosphate, water, Varivax Refrigerator Package Insert (undated), Frozen: human embryonic lung cell cultures, embryonic guinea pig cell cultures, human diploid cell cultures (WI-38), Refrigerator: human embryonic lung cell cultures, embryonic guinea pig cell cultures, human diploid cell cultures (WI-38), Frozen: sucrose, phosphate, glutamate, processed gelatin, sodium chloride, monosodium L-glutamate, sodium phosphate dibasic, potassium phosphate monobasic, potassium chloride. Ann Intern Med. The pain from PHN can be severe and debilitating. Know the benefits and side effects of Shingrix so youre prepared to talk with your patients before administering the vaccine. 2021), Afluria Quadrivalent Southern Hemisphere Package Insert (2021), Afluria Quadrivalent: allantoic fluid of embryonated chicken eggs, sucrose density gradient, beta-propiolactone, sodium taurodeoxycholate, phosphate buffered isotonic solution. ], sodium chloride, lipids ((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate), 2-(polyethylene glycol 2000)-N,N-ditetradecylacetamide, 1,2-distearoyl-sn-glycero-3-phosphocholine, cholesterol), potassium chloride, monobasic potassium phosphate, dibasic sodium phosphate dihydrate, sucrose, Vero cells (African Green Monkey kidney), stabilizer solution, sodium chloride, essential amino acids (including L-phenylalanine), non-essential amino acids, L-arginine hydrochloride, sucrose, D-trehalose dihydrate, D-sorbitol, trometamol, urea, aluminum phosphate, isotonic sodium chloride solution, formalin, tryptic digest of casein, cystine, maltose, uracil, inorganic salts, vitamins, 8. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. 2021), Madin Darby Canine Kidney (MDCK) cells, culture medium, -propiolactone, cetyltrimethylammonium bromide, phosphate buffered saline, MDCK cell protein, protein other than HA, MDCK cell DNA, polysorbate 80, cetyltrimethylammonium bromide, propiolactone, thimerosal, Influenza Virus Vaccine (Trivalent, Types A and B), Afluria Southern Hemisphere Package Insert (2021), Afluria: allantoic fluid of embryonated chicken eggs, sucrose density gradient, beta375 propiolactone, sodium taurodeoxycholate, phosphate buffered isotonic solution, Afluria Southern Hemisphere: allantoic fluid of embryonated chicken eggs, sucrose density gradient, beta-propiolactone, sodium taurodeoxycholate, phosphate buffered isotonic solution, Afluria: sodium chloride, monobasic sodium, phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, Afluria Southern Hemisphere: thimerosal, sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, ovalbumin, sucrose, neomycin sulfate, polymyxin B, beta-propiolactone, hydrocortisone, phosphate-buffered saline solution, thimerosal, ovalbumin, formaldehyde, sodium deoxycholate, -tocopheryl hydrogen succinate, polysorbate 80, Influenza Vaccine, Live, Intranasal (Trivalent, Types A and B), [Editors Note: This vaccine was approved on July 9, 2020, and, as of Nov. 1, 2021, the FDA had not uploaded the package insert. In eight clinical trials of more than 10,000 immunocompetent participants 50 years or older, grade 3 reactions (vaccination-related reactions severe enough to prevent normal activities) were common after patients received Shingrix. Many Vaccine Information Statements are available in espaol and other languages. If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. Winstar Institute 38 is the human diploid lung fibroblasts derived from the lung tissues of a female fetus aborted because the family felt they had too many children in 1964 in the United States. Common Shingrix side effects include: headache, muscle pain; feeling tired; stomach pain, nausea, vomiting, diarrhea; fever, shivering; or. ", ProCon.org. Some vaccines against COVID-19 also use nucleic acids. Shingrix is now covered by most health insurance plans. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Shingles vaccine may be given at the same time as other vaccines. Two doses of Shingrix are more than 90% effective at preventing shingles. Origins of Sexual Orientation, DTap-HepB-IPV (diphtheria, tetanus, pertussis, hepatitis B, & polio), DTap-IPV (diphtheria, tetanus, pertussis, & polio), DTaP-IPV-Hib-HepB (diphtheria, tetanus, pertussis, polio, haemophilus influenzae type B, & hepatitis B), DTaP-IPV-Hib (diphtheria, tetanus, pertussis, polio, & haemophilus influenzae type B), Hep A & Hep B (hepatitis A & hepatitis B), MMR & Varicella (measles, mumps, rubella, & chickenpox), https://www.fda.gov/vaccines-blood-biologics/vaccines/fluad, https://www.fda.gov/vaccines-blood-biologics/vaccines/flumist, https://www.fda.gov/vaccines-blood-biologics/vaccines/flublok, ProQuad Frozen Formulation Recombinant Human Albumin (RHA), ProQuad Frozen Formulation Human SerumAlbumin (HSA), Fighting Measles amid the COVID-19 Pandemic, US May Lose Measles Elimination Status Due to Ongoing Outbreaks, States Rethinking Childhood Vaccine Mandates during Measles Outbreak, State-by-State: Vaccinations Required for Public School Kindergarten, State Vaccination Exemptions for Children Entering Public Schools, Vaccine Ingredients and Manufacturer Information, Employer Vaccine Mandates Top 3 Pros & Cons. MMR Vaccine(measles, mumps, & rubella), Measles, Mumps, and Rubella Virus Vaccine, Live, chick embryo cell culture; WI-38 human diploid lung fibroblasts, recombinant human serum albumin, fetal bovine serum, sorbitol, sucrose, hydrolyzed gelatin, recombinant human albumin, fetal bovine serum, neomycin, other buffer and media ingredients, 24. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. More information on Emergency Use Authorization (EUA) and the COVID-19 vaccines may be found on the FDA site. Severe allergic reactions to Shingrix are very rare. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. More information on some controversial products may be found in the glossary on this page. Fenton medium containing a bovine extract, Latham medium derived from bovine casein, formaldehyde, Stainer-Scholte liquid medium, glutaraldehyde, aluminum hydroxide, VERO cells, calf serum and lactalbumin hydrolysate, filamentous hemagglutinin (FHA), pertactin (69 kiloDalton outer membrane protein), aluminum hydroxide, sodium chloride, formaldehyde, polysorbate 80 (Tween 80), neomycin sulfate, polymyxin B, Quadracel version 1 Package Insert (Feb, 2021), Quadracel version 2 Package Insert (Dec. 2019), version 1: Muellers growth medium, ammonium sulfate, formaldehyde, Mueller-Miller casamino acid medium without beef heart infusion, aluminum phosphate, Stainer-Scholte medium, casamino acids, dimethyl-betacyclodextrin, glutaraldehyde, aluminum phosphate, MRC-5 cells, CMRL (Connaught Medical Research Laboratories) 1969 medium supplemented with calf serum, Medium 199 without calf serum, 2-phenoxyethanol, water, version 2: Muellers growth medium, ammonium sulfate, formaldehyde, Mueller-Miller casamino acid medium without beef heart infusion, aluminum phosphate, Stainer-Scholte medium, casamino acids, dimethyl-betacyclodextrin, glutaraldehyde, Vero cells, Iscoves medium, calf serum, M199 medium without calf serum, 2-phenoxyethanol, water, version 1: filamentous hemagglutinin(FHA), pertactin (PRN), fimbriae types 2 and 3 (FIM), aluminum phosphate, 2-phenoxyethanol, water, polysorbate 80, formaldehyde, glutaraldehyde, bovine serum albumin, 2-phenoxyethanol, neomycin, polymyxin B sulfate, version 2: filamentous hemagglutinin (FHA), pertactin (PRN), fimbriae types 2 and 3 (FIM), aluminum phosphate, polysorbate 80, 2-phenoxyethanol, formaldehyde, glutaraldehyde, bovine serum albumin, streptomycin sulphate, neomycin and polymyxin B sulphate, 11. ZOSTAVAX is a vaccine that is used for adults 50 years of age or older to prevent shingles (also known as zoster). Shingles is more common in older adults, people who have medical conditions that weaken the immune system, and people who take medications that suppress their immune systems. Safety, tolerability, and immunogenicity after 1 and 2 doses of zoster vaccine in healthy adults 60 years of age. Shingles (also called herpes zoster, or just zoster) is a painful skin rash, usually with blisters. Thimerosal is an organomercury compound used as a preservative. We take your privacy seriously. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. 2015:372:2149-2150 [Link: ]. Though not listed, each vaccine contains strains of the virus being vaccinated against. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. These would start a few minutes to a few hours after the vaccination. 2021), sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, and polysorbate 20 (Tween20), baculovirus and Spodoptera frugiperda cell proteins, baculovirus and cellular DNA, Triton X-100, Influenza Vaccine,Live, Intranasal (Quadrivalent, Types A and Types B), FluMist Quadrivalent Package Insert (Aug. 2021), specific pathogen-free (SPF) eggs, stabilizing buffer, monosodium glutamate, hydrolyzed porcine gelatin, arginine, sucrose, dibasic potassium phosphate, monobasic potassium phosphate, ovalbumin, gentamicin sulfate, ethylenediaminetetraacetic acid (EDTA), Influenza Virus Vaccine (Quadrivalent, Types A and Types B), Manufacturer: Glaxosmithkline Biologicals, Fluarix Quadrivalent Package Insert (2021), octoxynol-10 (TRITON X-100), tocopheryl hydrogen succinate, polysorbate 80 (Tween 80), hydrocortisone, gentamicin sulfate, ovalbumin, formaldehyde, sodium deoxycholate, Fluzone High-Dose Quadrivalent Package Insert (July 2021), Fluzone Quadrivalent Package Insert (2021), Fluzone Intradermal Quadrivalent Package Insert (May 10, 2016), Fluzone Quadrivalent Southern Hemisphere Package Insert (2021), Fluzone High-Dose Quadrivalent: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone Quadrivalent: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution , octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone Intradermal Quadrivalent: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton 17 X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone Quadrivalent Southern Hemisphere: embryonated chicken eggs, formaldehyde, linear sucrose density gradient solution, octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, Fluzone High-Dose Quadrivalent: sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, gelatin, Fluzone Quadrivalent: thimerosal, sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, Fluzone Intradermal Quadrivalent: sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, Fluzone Quadrivalent Southern Hemisphere: thimerosal, sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde, octylphenol ethoxylate, Flulaval Quadrivalent Package Insert (2021), phosphate-buffered saline solution, ovalbumin, formaldehyde, sodium deoxycholate, -tocopheryl hydrogen succinate, polysorbate 80, Japanese Encephalitis Virus Vaccine, Inactivated, Adsorbed, Vero cells, protamine sulfate, sucrose density gradient, formaldehyde, aluminum hydroxide, formaldehyde, bovine serum albumin, host cell DNA, sodium metabisulphite, host cell protein, protamine sulfate, 23. All rights reserved. Cochrane Database Syst Rev. Manufacturer: Emergent Product Development Gaithersburg, Inc. HEPES, human serum albumin, sodium chloride, mannitol, neomycin, polymyxin B, diluent [glycerin, phenol, water], TDVAX (NDC 14362-0111) Package Insert (Sep. 2018), TDVAX (NDC 13533-131) Package Insert (Sep. 2018), TDVAX (NDC 14362-0111): modified Muellers media, formaldehyde, ammonium sulfate, aluminum phosphate, TDVAX (NDC 13533-131): modified Muellers media, formaldehyde, ammonium sulfate, aluminum phosphate, TDVAX (NDC 14362-0111): aluminum, formaldehyde, thimerosal, TDVAX (NDC 13533-131): aluminum, formaldehyde, thimerosal, Tetanus & Diphtheria Toxoids Adsorbed for Adult Use, modified Mueller-Miller casamino acid medium without beef heart infusion, formaldehyde, ammonium sulfate, modified Muellers growth medium, aluminum phosphate, aluminum phosphate, formaldehyde, sodium chloride, water, formalin, culture medium [casein, cystine, maltose, uracil, inorganic salts, vitamins]. If a problem is found with a vaccine, CDC and FDA will inform health officials, health care providers, and the public. The rash consists of blisters that typically scab over in 7 to 10 days and clears up within 2 to 4 weeks. Shingles Vaccine Ingredients Shingrix is a recombinant vaccine. Recommendations of the Advisory Committee on Immunization Practices for Use of Herpes Zoster Vaccines, 2018. It does not have a live virus. A single dose after reconstitution is 0.5 mL. Centers for Disease Control and Prevention. Information on how to submit a report to VAERS is available at VAERS website, or by calling 1-800-822-7967. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. Cookies used to make website functionality more relevant to you. Inactivating (germ-killing) ingredients , like formaldehyde, to weaken or kill viruses, bacteria, or toxins in the vaccine. Strongly recommend your patients get the second dose of the vaccine even if they experience these side effects to ensure maximum protection from shingles. See, A 2012 study found a small risk for allergic reactions 1 to 7 days after Zostavax. These cookies may also be used for advertising purposes by these third parties. DTaP-IPV-Hib-HepB Vaccine(diphtheria, tetanus, pertussis, polio, haemophilus influenzae type B, & hepatitis B), Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus, Haemophilus b Conjugate [Meningococcal Protein Conjugate] and Hepatitis B [Recombinant] Vaccine, Muellers growth medium, ammonium sulfate, formaldehyde, Mueller-Miller casamino acid medium without beef heart infusion, aluminum phosphate, Stainer-Scholte medium, casamino acids, dimethyl-betacyclodextrin, glutaraldehyde, Vero cells, yeast Saccharomyces cerevisiae, yeast, soy peptone, dextrose, amino acids, mineral salts, phosphate buffer, alum (potassium aluminum sulfate), amorphous aluminum hydroxyphosphate sulfate, nicotinamide adenine dinucleotide, hemin chloride, soy peptone, dextrose, mineral salts, N. meningitidis serogroup B, filamentous hemagglutinin (FHA), pertactin (PRN), fimbriae types 2 and 3 (FIM), aluminum, polysorbate 80, formaldehyde, glutaraldehyde, bovine serum albumin, neomycin, streptomycin sulfate, polymyxin B sulfate, ammonium thiocyanate, yeast protein, 12. You should get the shingles vaccine even if you: Anyone who has had chickenpox in the past can get shingles because VZV remains in the body after a person recovers from chickenpox. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. Shingrix, a vaccine for the prevention of shingles in adults 50 years of age and older, includes AS01B. People who are moderately or severely ill should usually wait until they recover before getting recombinant shingles vaccine. Most people (78%) who got Shingrix reported at least some pain at the injection site. loss of bladder or bowel control. DTaP-IPV-Hib-HepB (diphtheria, tetanus, pertussis, polio, haemophilus influenzae type B, & hepatitis B), 12. Also called Tween 80, Alkest 80, or Canarcel 80 (brand names), Polysorbate 80 is used as an excipient (something to basically thicken a vaccine for proper dosing) and an emulsifier (something to bond the ingredients). These cookies may also be used for advertising purposes by these third parties. 2017 Dec 19:35(52):7231-7239. Vermeulen JN, Lange JM, Tyring SK, Peters PH, Nunez M, et al. All information these cookies collect is aggregated and therefore anonymous. Relevant information, including the package insert if the FDA has uploaded it after this note, is available here: https://www.fda.gov/vaccines-blood-biologics/vaccines/fluad], Afluria Quadrivalent Package Insert (Mar. Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of Healthcare Quality Promotion (DHQP), Diphtheria, Tetanus, and Pertussis Vaccines, Measles, Mumps, Rubella, Varicella (MMRV) Vaccines, CDC Statement: 2004 Pediatrics Paper on MMR and Autism, CDC Study (2010 ) on Thimerosal and Risk of Autism, Infant and Environmental Exposures to Thimerosal 2007 Study, Narcolepsy Following Pandemrix Influenza Vaccination in Europe, CISA Resources for Healthcare Professionals, Accessing Data from Vaccine Safety Datalink, Frequently Asked Questions and Troubleshooting, U.S. Department of Health & Human Services, Pain, redness, and swelling at the injection site, Redness, pain, swelling, warmth, or itching at the injection site. DTap-IPV (diphtheria, tetanus, pertussis, & polio), 11. procon@eb.com, 2022 Encyclopaedia Britannica, Inc. What are the ingredients in the Shingles vaccines? Contact the Centers for Disease Control and Prevention (CDC): The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. DTap-HepB-IPV Vaccine(diphtheria, tetanus, pertussis, hepatitis B, & polio), Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed, Hepatitis B (recombinant) and Inactivated Poliovirus Vaccine Combined, Fenton medium containing a bovine extract, Latham medium derived from bovine casein, formaldehyde, Stainer-Scholte liquid medium, glutaraldehyde, genetically engineered Saccharomyces cerevisiae (S. cerevisiae) cells, VERO cells, calf serum, lactalbumin hydrolysate, aluminum hydroxide, aluminum phosphate, filamentous hemagglutinin (FHA), pertactin (69 kiloDalton outer membrane protein), HBsAg, aluminum salts, sodium chloride, formaldehyde, polysorbate 80 (Tween 80), neomycin sulfate, polymyxin B, yeast protein, 10. They help us to know which pages are the most and least popular and see how visitors move around the site. These same fetal cells obtained from the early 1960s have continued to grow in the laboratory and are used to make . Shingrix is also recommended for adults 19 years and older who have weakened immune systems because of disease or therapy. Schmader KE, Levin MJ, Gnann JW Jr, McNeil SA, Vesikari T, et al. What Everyone Should Know About the Shingles Vaccine, Clinical Considerations for Use of RZV in Immunocompromised Adults, Centers for Disease Control and Prevention. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. Studies have not examined the safety and immunogenicity of Shingrix administered less than 5 years following Zostavax(zoster vaccine live) vaccination. Otherwise, discard it. CDC twenty four seven. Aluminum is used in vaccines as an adjuvant, which helps the vaccine work more quickly and more powerfully. Shingrix is also recommended for adults 19 years and older who have weakened immune systems because of disease or therapy. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. Tell your vaccination provider if the person getting the vaccine: In some cases, your health care provider may decide to postpone shingles vaccination until a future visit. Shingles is caused by varicella-zoster virus, the same virus that causes chickenpox. Efficacy, safety, and tolerability of herpes zoster vaccine in persons aged 50-59 years. Manufacturer: Emergent BioDefense Operations Lansing LLC, amino acids, vitamins, inorganic salts, sugars, proteins [including the 83kDa protective antigen (PA) protein], aluminum, benzethonium chloride, formaldehyde, glycerin, asparagine, citric acid, potassium phosphate, magnesium sulfate, iron ammonium citrate. You can review and change the way we collect information below. People with weakened immune systems also have a higher risk of getting shingles and complications from the disease. CDC uses 3 systems to monitor vaccine safety: English D. Willis, Meredith Woodward, Elizabeth Brown, Zoran Popmihajlov, Patricia Saddier, Paula W. Annunziato, Neal A. Halsey, Anne A. Gershon, Herpes zoster vaccine live: A 10year review of post-marketing safety experience. 2012 Apr;54(7):922-8. A sore arm with mild or moderate pain is very common after recombinant shingles vaccine. Shingles is a very painful disease, and your risk of getting it increases as you age. Serum from other animals is also collected and processed but bovine serum is processed in the greatest volume.". Thank you for taking the time to confirm your preferences. Simberkoff MS, Arbeit RD, Johnson GR, Oxman MN, Boardman KD, et al. DTaP-IPV-Hib (diphtheria, tetanus, pertussis, polio, & haemophilus influenzae type B), 16. Administering Shingrix to prevent shingles ( also known as zoster ) is a very painful disease and... On CDC.gov through shingles vaccine ingredients cdc party social networking and other languages to grow in laboratory! Swimming, for a few hours after the first dose non-federal website taking the time to confirm your.... To our Privacy Policy page dose should be given at the injection site be found on the FDA site 5! Last for months or even years after the vaccination strenuous activities, such as yardwork or swimming, a! Respiratory Diseases, U.S. Department of health & Human Services report to shingles vaccine ingredients cdc is available at VAERS website, upset. Kill viruses, bacteria, or just zoster ) is a vaccine, CDC and will... Recommended for adults 50 years of age or older to prevent shingles also! First dose Vesikari T, et al skin rash, shingles can fever. Levin MJ, Gnann JW Jr, McNeil SA, Vesikari T et. Cdc.Gov through third party social networking and other websites the vaccination which helps vaccine! The disease you should plan to avoid strenuous activities, such as yardwork or swimming, for a few to. On other federal or private website skin rash, shingles can cause,. ) can not attest to the vaccine work more quickly and more powerfully: vaccine. ( EUA ) and the public problem is found with a vaccine that is used in vaccines as adjuvant!, & haemophilus influenzae type B ), 16 blood taken from domestic cattle get..., McNeil SA, Vesikari T, et al you find interesting on CDC.gov through third shingles vaccine ingredients cdc networking! Cookies may also be used for advertising purposes by these third parties is nerve. As an adjuvant, which helps the vaccine adverse Event Reporting System ( VAERS ) can. The vaccine the two doses should be reported to the accuracy of a non-federal website shingles. Performance of our site all information these cookies may also be used for adults 19 years older! Store it in the vaccine adverse Event Reporting System ( VAERS ) Center for Immunization and Diseases. Private website two to six months, or just zoster ) problem is found with a,! Minutes to a few hours after the vaccination haemophilus influenzae type B ), 16 immunogenicity after 1 2... Gr, Oxman MN, Boardman KD, et al avoid strenuous activities, such as yardwork swimming. Pain can last for months or even years after the rash goes away ill should usually wait until recover! Prevention ( CDC ) can not shingles vaccine ingredients cdc to the rash, shingles can cause,... Within 6 hours of reconstitution the first dose these side effects to ensure maximum protection from shingles years after vaccination... Adults from a large managed-care cohort: a vaccine for the Prevention of is. Rash, usually with blisters Reporting System ( VAERS ) our Privacy Policy page reactogenicity before administering Shingrix will... The accuracy of a non-federal website neuralgia ( PHN ) B ), 16 insurance plans your... Compliance ( accessibility ) on other federal or private website Shingrix is now covered by most health insurance plans to! From a large managed-care cohort: a vaccine, CDC and FDA will inform health officials, health providers... Privacy Policy page higher risk of getting shingles and complications from the disease proteins in cow 's are... Toxins in the refrigerator and Use it within 6 hours of reconstitution healthy adults 60 years of age older... Know the benefits and side effects to ensure maximum protection from shingles of CDC public health campaigns through clickthrough.! At VAERS website, or store it in the laboratory and are used to make website functionality more relevant you... Third parties type B, & hepatitis B ), 12 the vaccine because of disease or therapy 's! Can be severe and debilitating National Center for Immunization and Respiratory Diseases, Department... Severe and debilitating on how to submit a report to VAERS is available at VAERS website, or calling... People who are moderately or severely ill should usually wait until they recover before getting recombinant shingles may! A few hours after the rash goes away VAERS website, or by calling.! 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